Percocet vs Vicodin: Oxycodone vs Hydrocodone Potency
Percocet and Vicodin both combine a central opioid with acetaminophen to achieve synergistic analgesia. The critical difference is the core opioid: Percocet utilizes oxycodone, which binds with higher affinity to mu-opioid receptors. Vicodin uses hydrocodone, which tends to produce slightly more antitussive and calming sedative effects.
Feature-by-Feature Comparison
Percocet
Vicodin
| Feature / Capability | Percocet | Vicodin |
|---|---|---|
| Opioid Component | Oxycodone HCl | Hydrocodone Bitartrate |
| Non-Opioid Partner | Acetaminophen (325mg) | Acetaminophen (300/325mg) |
| Relative Potency | 1.5x stronger than Hydrocodone | Baseline opioid potency |
| Common Strengths | 5/325mg, 7.5/325mg, 10/325mg | 5/300mg, 7.5/300mg, 10/300mg |
| Onset of Action | 15-30 minutes | 20-30 minutes |
| Duration of Relief | 3 to 6 hours | 4 to 6 hours |
| Starting Price | $190.00 – $590.00 | $100.00 – $380.00 |
| View Percocet | View Vicodin |
The Final Verdict
Percocet is roughly 1.5 times more potent milligram-for-milligram than Vicodin due to its oxycodone core, making it effective for severe post-surgical and breakthrough pain. Vicodin is widely prescribed for moderate-to-severe orthopedic and dental recovery.
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. The accuracy of pricing and features may change over time. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication.
Last updated: September 2026